Cellular electrophysiology of digitalis toxicity
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چکیده
منابع مشابه
Cellular electrophysiology of digitalis toxicity.
The toxic effects of digitalis are attributable in part to poisoning of the enzyme Na+-K+ ATPase and in part to the interactions of digitalis with the sympathetic and parasympathetic nervous systems. Additional modifiers of the toxic effects of digitalis include the concentrations of ions such as K+ and Ca2+, the age of the subject and the extent and type of cardiac disease. At the cellular ele...
متن کاملDigitalis toxicity.
Digitalis toxicity is a frequently encountered clinical problem. Drug interactions leading to digitalis toxicity are very common. Within this group, the interaction of digitalis and verapamil is increasingly recognized as an important cause of digitalis toxicity. The use of digoxin-binding antibodies represents a significant advance in the treatment of this problem and can be lifesaving in the ...
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Toxicity from the digitalis family of cardiac glycoside medications remains common. Successful treatment depends on early recognition; however, the diagnosis of potentially life-threatening toxicity remains difficult because the clinical presentation is often nonspecific and subtle. The hallmark of cardiac toxicity is increased automaticity coupled with concomitant conduction delay. Though no s...
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A. H., a 77-year-old woman, was admitted to the Williamsburgh General Hospital on October 5, 1955, with a history of left radical mastectomy for malignant disease 15 years previously with no recurrence to date. Hypertension was of many years' duration. She had shown slight evidences of congestive heart failure some months prior to admission, had been digitalized, and was comfortable on a mainte...
متن کاملInfluence of Induced Hypothermia on Digitalis Toxicity
PREVIOUS studies on the effect of digitalis on the hypothermic heart have indicated that the arrhythmic effects of hypothermia and digitalis are antagonistic. Those experiments were primarily intended to study the effect of digitalization on hypothermia using pharmacological doses of digitalis. In the experiments reported herein, the procedure was reversed in that it was thought to be of value ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1985
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(85)80460-5